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SML3450

Sigma-Aldrich

PA-8

≥95% (HPLC)

Synonym(s):

2-​Amino-​5,​8-​dihydro-​5-​[3-​methoxy-​4-​(2-​propen-​1-​yloxy)​phenyl]​-pyrido[2,​3-​d]​pyrimidine-​4,​7(3H,​6H)​-​dione, PA 8

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About This Item

Empirical Formula (Hill Notation):
C17H18N4O4
CAS Number:
878437-15-1
Molecular Weight:
342.35
MDL number:
MFCD07400226
UNSPSC Code:
12352200
NACRES:
NA.77

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Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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This Item
MABN2440MABN287MABN893
Anti-ABCA4 from rabbit, purified by affinity chromatography

ABN1441

Anti-ABCA4

Anti-ABCA4 Antibody, clone 5B4 clone 5B4, from mouse

MABN2440

Anti-ABCA4 Antibody, clone 5B4

Anti-ABCA4 Antibody, clone 5D7.1 clone 5D7.1, from mouse

MABN287

Anti-ABCA4 Antibody, clone 5D7.1

Anti-ABCA1 Antibody, clone MABI98-7 clone MAB198-7, from rat

MABN893

Anti-ABCA1 Antibody, clone MABI98-7

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified immunoglobulin

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

mouse

biological source

mouse

biological source

rat

UniProt accession no.

P78363

UniProt accession no.

P78363

UniProt accession no.

P78363

UniProt accession no.

P41233

clone

polyclonal

clone

5B4, monoclonal

clone

5D7.1, monoclonal

clone

MAB198-7, monoclonal

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

technique(s)

immunohistochemistry: suitable, western blot: suitable

Biochem/physiol Actions

PA-8 is a potent and selective PACAP type I (PAC1) receptor agonist that inhibits the phosphorylation of CREB induced by PACAP in PAC1- receptor-expressing CHO cells. PA-8 blocks PACAP-induced aversive responses and mechanical allodynia in mice.
Potent and selective PACAP type I (PAC1) receptor antagonist.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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