SML3858

SAFit2

≥98% (HPLC)

• Synonym(s): (S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carboxylate, [(1R)-3-(3,4-Dimethoxyphenyl)-1-[3-(2-morpholin-4-ylethoxy)phenyl]propyl] (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate
• Empirical Formula (Hill Notation): C₄₆H₆₂N₂O₁₀
• CAS Number: 1643125-33-0
• Molecular Weight: 802.99
• MDL number: MFCD31619236
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: O=C([C@@H](C1CCCCC1)C2=CC(OC)=C(C(OC)=C2)OC)N3CCCC[C@H]3C(O[C@@H](C4=CC(OCCN5CCOCC5)=CC=C4)CCC(C=C6)=CC(OC)=C6OC)=O
• InChI: 1S/C46H62N2O10/c1-51-39-20-18-32(28-40(39)52-2)17-19-38(34-14-11-15-36(29-34)57-27-24-47-22-25-56-26-23-47)58-46(50)37-16-9-10-21-48(37)45(49)43(33-12-7-6-8-13-33)35-30-41(53-3)44(55-5)42(31-35)54-4/h11,14-15,18,20,28-31,33,37-38,43H,6-10,12-13,16-17,19,2
• InChI key: ZDBWLRLGUBSLPG-FDHYQTMZSA-N

Description

Biochem/physiol Actions

Potent and selective FK506-binding protein 51 (FKBP51) inhibitor that stimulates neurite growth in cultures and exhibits antidepressant-like effects in vivo.



SAFit2 is a brain-penetrant, potent and selective FK506-binding protein 51 inhibitor (Ki = 6 nM/FKBP51 vs. >50 μM/FKBP52) that enhances neurite growth in murine Neuro 2A (N2a) cultures (1-10 nM) and improves neuroendocrine feedback and stress-coping behavior in mice in vivo (20 mg/kg i.p.).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable