SML4082

Paliperidone Palmitate

≥98% (HPLC)

• Synonym(s): 3-(2-(4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl palmitate, 9-Hydroxyrisperidone palmitate, Hexadecanoic acid 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester, RO 92670
• Empirical Formula (Hill Notation): C₃₉H₅₇FN₄O₄
• CAS Number: 199739-10-1
• Molecular Weight: 664.89
• MDL number: MFCD24386477
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: soluble (DMSO:TFA, 2 mg/mL, clear (add 1 drop TFA))
• storage temp.: -10 to -25°C
• SMILES string: Fc1cc2[o]nc(c2cc1)C3CCN(CC3)CCC4=C(NC5=C(CCCN5C4=O)OC(=O)CCCCCCCCCCCCCCC)C
• InChI key: YOSKWMGLLZWACB-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Prodrug form of paliperidone, is a long-acting injectable antipsychotic that targets dopamine and serotonin receptors.


Paliperidone palmitate is a long-acting injectable form of paliperidone, an atypical antipsychotic that targets dopamine D2 and serotonin 5-HT2A receptors to alleviate schizophrenia symptoms through neurotransmission regulation. Paliperidone palmitate also interacts with α1/α2 adrenergic and H1 histaminergic receptors, influencing both its therapeutic effects and side effect profile. The formulation′s sustained release mechanism promotes gradual absorption, ensuring stable drug levels for prolonged efficacy.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable