T2057

Trequinsin hydrochloride

≥98%

• Synonym(s): HL 725
• Empirical Formula (Hill Notation): C₂₄H₂₇N₃O₃ · HCl
• CAS Number: 78416-81-6
• Molecular Weight: 441.95
• MDL number: MFCD01076563
• UNSPSC Code: 41106305
• PubChem Substance ID: 24278727
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98%
• form: powder
• SMILES string: Cl[H].COc1cc2CCN3C(=O)N(C)C(\C=C3c2cc1OC)=N\c4c(C)cc(C)cc4C
• InChI: 1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;
• InChI key: DTCZZBVPTHVXFA-OSMRDGEFSA-N
• Gene Information: human ... PDE3A(5139), PDE3B(5140)

Description

Application

Trequinsin has been used as a PDE3 inhibitor in rat juxtaglomerular cells. This study reported that trequinsin can enhance cellular cAMP content, forskolin-induced cAMP synthesis, and renin release in cells.

Biochem/physiol Actions

Phosphodiesterase III inhibitor.

Trequinsin is a strong antihypertensive agent that has a hemodynamic profile similar to that of arteriolar dilators. Trequinsin can block platelet aggregation and also inhibit tissue factor expression in human endothelial cells,.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves