T2067

Tyrphostin AG 879

99% (HPLC)

• Synonym(s): α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
• Empirical Formula (Hill Notation): C₁₈H₂₄N₂OS
• CAS Number: 148741-30-4
• Molecular Weight: 316.46
• MDL number: MFCD00236450
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278728
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: 99% (HPLC)
• solubility: DMSO: soluble (at 26 mg/ml); H₂O: insoluble
• SMILES string: CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
• InChI key: XRZYELWZLNAXGE-KPKJPENVSA-N
• Gene Information: human ... ERBB2(2064), NTRK1(4914)

Description

Application

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation¹. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation².

Biochem/physiol Actions

Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells³. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice⁴.

Features and Benefits

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Preparation Note

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves