T3068

Thrombin generation chromogenic substrate

≥90% (HPLC), solid

• Synonym(s): β-Ala-Gly-Arg-p-nitroanilide diacetate
• Empirical Formula (Hill Notation): C₂₁H₃₄N₈O₉
• Molecular Weight: 542.54
• MDL number: MFCD03453625
• UNSPSC Code: 12352204
• NACRES: NA.32

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥90% (HPLC)
• form: solid
• technique(s): activity assay: suitable
• storage temp.: 2-8°C
• SMILES string: [N+](=O)([O-])c1ccc(cc1)NC(=O)[C@@H](NC(=O)CNC(=O)CCN)CCCNC(=N)N.OC(=O)C.OC(=O)C
• InChI key: PBMJNSQKWBTVOL-GXKRWWSZSA-N

Description

Amino Acid Sequence

Ala-Gly-Arg-pNA

Application

Thrombin generation chromogenic substrate can be used for chromogenic assay developed through aptamer affinity capture and a subsequent enzyme reaction for detecting the thrombin in dilute human serum.

Biochem/physiol Actions

Thrombin generation chromogenic substrate also known as beta-Ala-Gly-Arg para-nitroanilide, is proteolytically cleaved by human thrombin and produces beta-Ala-Gly-Arg and p-nitroanilide. The release of p-nitroanilide is quatified for assesing the anti-thrombin activity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves