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U6750

Sigma-Aldrich

Uridine 5′-triphosphate trisodium salt hydrate

Type IV, ≥93.0% (HPLC)

Synonym(s):

UTP Na3

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25 G
₩235,683
100 G
₩932,481

₩235,683


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25 G
₩235,683
100 G
₩932,481

About This Item

Empirical Formula (Hill Notation):
C9H12N2Na3O15P3 · xH2O
CAS Number:
Molecular Weight:
550.09 (anhydrous basis)
Beilstein:
3585234
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

₩235,683


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type

Type IV

Quality Level

Assay

≥93.0% (HPLC)

solubility

H2O: soluble 25 mg of UTP in 0.5 ml of solvent, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O

InChI

1S/C9H15N2O15P3.3Na/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1

InChI key

MMJGIWFJVDOPJF-LLWADOMFSA-K

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1 of 4

This Item
PHR2577PHR2784PHR2783
grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, pharmaceutical secondary standard

application(s)

pharmaceutical

application(s)

pharmaceutical small molecule

application(s)

pharmaceutical small molecule

application(s)

pharmaceutical small molecule

form

powder

form

solid

form

powder

form

solid

agency

traceable to Ph. Eur. Y0000412

agency

traceable to USP 1631533

agency

-

agency

traceable to Ph. Eur. M0600905

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

-

description

-

description

-

API family

sulfamethoxazole

API family

sulfamethoxazole

API family

metamizole

API family

metamizole

Application

UTP has been used as a P2 receptor activator to study its effects on proton efflux in MC3T3-E1 and UMR-106 cells[1]. UTP has also been studied in combination with amiloride hydrochloride in nebulizer solutions for treating cystic fibrosis[2].
Uridine 5′-triphosphate has been used in a study to show that fluoxetine (FLX), mediates its anti-depressive effect by increasing the gliotransmission of adenosine 5′-triphosphate (ATP).[3]

Biochem/physiol Actions

P2Y receptor agonist.
Uridine-5′-Triphosphate (UTP) is a cytosolic nucleotide component of nucleic acids. It serves as a signaling molecule in the extracellular space.[4] Uridine-5′-Triphosphate (UTP) is involved in various pathophysiological responses in the nervous system. UTP also plays a major role in the regeneration process.[5]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

25 mg of Uridine 5′-triphosphate trisodium salt (UTP Na3) hydrate is soluble in 0.5 ml of water and yields a clear, colorless solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Spectrophotometric microdetermination of amines and sulfamates with 1,4-Benzoquinone.
    G A Benson et al.
    Analytical chemistry, 48(14), 2149-2152 (1976-12-01)
    Preparation, characterization and application of alkanethiol self-assembled monolayers modified with tetrathiafulvalene and glucose oxidase at a gold disk electrode.
    Campuzano S
    Journal of Electroanalytical Chemistry, 526 (1), 92-100 (2002)
    Peroxide-initiated crosslinking of polypropylene in the presence of p-benzoquinone.
    Chodak I and Lazar M.
    Journal of Polymer Science: Part A, General Papers, 32 (6), 5432-5437 (1986)
    D A Zaia et al.
    Talanta, 50(5), 1003-1010 (2008-10-31)
    A simple, sensitive, and selective method has been developed for determination of cysteine (Cys) or carbocysteine (carboCys) in pharmaceutical products, shampoos and a mixture of amino acids. The results showed the reaction between p-benzoquinone (PBQ) and Cys occurs through the
    Vandana Bhalla et al.
    Dalton transactions (Cambridge, England : 2003), 42(4), 975-980 (2012-11-21)
    A pentaquinone based compound 3a has been synthesized which undergoes significant fluorescence enhancement in the presence of Zn(2+) ions with a detection limit up to nanomolar range in THF. Further, the zinc ensemble of 3a is evaluated for its anti-oxidizing

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