V1255

D-Valine

BioReagent, suitable for cell culture

• Synonym(s): (R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid
• Linear Formula: (CH₃)₂CHCH(NH₂)CO₂H
• CAS Number: 640-68-6
• Molecular Weight: 117.15
• Beilstein: 1721135
• EC Number: 211-368-9
• MDL number: MFCD00064219
• UNSPSC Code: 12352209
• PubChem Substance ID: 24900713
• NACRES: NA.75

Properties

• biological source: synthetic (organic)
• product line: BioReagent
• form: powder
• technique(s): cell culture | mammalian: suitable
• mp: >295 °C (subl.) (lit.)
• shipped in: ambient
• storage temp.: room temp
• SMILES string: CC(C)[C@@H](N)C(O)=O
• InChI: 1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1
• InChI key: KZSNJWFQEVHDMF-SCSAIBSYSA-N

Description

General description

L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.

Application

D-Valine has been used as a supplement in:

• Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture
• endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture
• DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture

Biochem/physiol Actions

D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.

D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves