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WH0007345M1

Sigma-Aldrich

Monoclonal Anti-UCHL1 antibody produced in mouse

clone 1B8-4D2, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-PARK5, Anti-PGP9.5, Anti-ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1B8-4D2, monoclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG1κ

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Monoclonal Anti-UCHL1 antibody produced in mouse clone 1B8-4D2, purified immunoglobulin, buffered aqueous solution

WH0007345M1

Monoclonal Anti-UCHL1 antibody produced in mouse

Monoclonal Anti-UCHL1 antibody produced in mouse clone S1, purified immunoglobulin, buffered aqueous solution

SAB1404510

Monoclonal Anti-UCHL1 antibody produced in mouse

Monoclonal Anti-KLHL1 antibody produced in mouse clone 3C2, purified immunoglobulin, buffered aqueous solution

SAB1403331

Monoclonal Anti-KLHL1 antibody produced in mouse

Monoclonal Anti-FHL1 antibody produced in mouse clone 2A9, purified immunoglobulin, buffered aqueous solution

WH0002273M1

Monoclonal Anti-FHL1 antibody produced in mouse

clone

1B8-4D2, monoclonal

clone

S1, monoclonal

clone

3C2, monoclonal

clone

2A9, monoclonal

Gene Information

human ... UCHL1(7345)

Gene Information

human ... UCHL1(7345)

Gene Information

human ... KLHL1(57626)

Gene Information

human ... FHL1(2273)

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

human, rat, mouse

species reactivity

human

species reactivity

human

species reactivity

rat, human, mouse

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

General description

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease
Ubiquitin C-terminal hydrolase L1 (UCHL1) is encoded by the gene mapped to human chromosome 4p14. The encoded protein is a deubiquitinase, which is part of the ubiquitin proteasome system (UPS). UCHL1 is specifically expressed in the nervous system and gonads.

Immunogen

UCHL1 (AAH00332, 1 a.a. ~ 223 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA

Biochem/physiol Actions

Ubiquitin C-terminal hydrolase L1 (UCHL1) catalyzes the hydrolysis of carboxy-terminal ubiquitin esters and amides. It plays an essential role in epithelial-mesenchymal transition. In addition, UCHL1 is also implicated in the cell invasion and in the cell cycle regulation. UCHL1 gene acts as an oncogene in various types of cancers including glioma, gastric cardiac adenocarcinoma (GCA) and colorectal cancer. It also acts as a susceptibility gene for Parkinson′s disease.

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    CB131-S5
    09321-S5
    08179-S5

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    Evaluation and quantification of potent odorants of Greek virgin olive oils.
    Blekas G & Guth H.
    Developments in food science, 37, 419-427 (1995)
    Evaluation of aroma differences between hand-squeezed juices from Valencia late and Navel oranges by quantitation of key odorants and flavor reconstitution experiments.
    Buettner A & Schieberle P.
    Journal of Agricultural and Food Chemistry, 49(5), 2387-2394 (2001)
    Evaluation of key aroma compounds in hand-squeezed grapefruit juice (Citrus paradisi Macfayden) by quantitation and flavor reconstitution experiments.
    Buettner A & Schieberle P.
    Journal of Agricultural and Food Chemistry, 49(3), 1358-1363 (2001)
    Philippe Renault et al.
    International journal of food microbiology, 207, 40-48 (2015-05-24)
    The aim of this work was to study ester formation and the aromatic impact of Torulaspora delbrueckii when used in association with Saccharomyces cerevisiae during the alcoholic fermentation of must. In order to evaluate the influence of the inoculation procedure
    Georgia Lytra et al.
    Food chemistry, 194, 196-200 (2015-10-17)
    Our study focused on variations in wine aroma perception and molecular composition during tasting over a period of 30min. In parallel, dynamic analytical and sensory methods were applied to study changes in the wines' molecular and aromatic evolution. Dynamic sensory
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    Protocols

    GC Analysis of Fermentation Compounds on a Packed Column (6.6% Carbowax® 20M on 80/120 Carbopack™ B AW)

    Separation of Acetone; Acetic acid; Propionic acid; Ethyl butyrate; Ethanol; Isoamyl acetate; Isobutyric acid; 3-Methyl-2-butanol; Methyl acetate; 1-Propanol; Acetal, ≥98%, FG; 2-Methyl-1-pentanol; Butyl acetate; Ethyl propionate; 3-Pentanol; 2-Pentanol, 98%; Ethyl isobutyrate; Isobutyl acetate; Acetaldehyde; Furfural; Butyric acid; Methanol; Ethyl acetate

    Chromatograms

    application for HPLCapplication for HPLC

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