Z0877

Zotepine

• Synonym(s): 2-[(8-chlorodibenzo[b,f]-thiepin-10-yl)oxy]-N,N-dimethylethanamine
• Empirical Formula (Hill Notation): C₁₈H₁₈ClNOS
• CAS Number: 26615-21-4
• Molecular Weight: 331.86
• MDL number: MFCD00868143
• UNSPSC Code: 12352200
• PubChem Substance ID: 329831602
• NACRES: NA.77

Properties

• Assay: >98% (HPLC)
• Quality Level: 100
• form: powder
• color: white to off-white
• solubility: DMSO: ≥20 mg/mL
• originator: Astellas
• storage temp.: room temp
• SMILES string: CN(C)CCOC1=Cc2ccccc2Sc3ccc(Cl)cc13
• InChI: 1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3
• InChI key: HDOZVRUNCMBHFH-UHFFFAOYSA-N

Description

Application

Zotepine has been used as an anti-psychotic agent:

• in biophysical studies with serotonin 2A receptor (5-HT_2AR)
• to study its effects on the inhibition of human organic cation transporter 1 (hOCT1)
• to study its protective effects on the human embryonic kidney (HEK cells)

Biochem/physiol Actions

Zotepine acts as an antagonist of dopamine D1, D2, and serotonin (5-HT_2A/2C) receptors, and noradrenaline transporters. It shows therapeutic effects against schizophrenia and acute mania.

Zotepine is an atypical antipsychotic.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Astellas. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302,H410
• Precautionary Statements: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable