T4143

Triamterene

≥99%

• Synonym(s): 2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine
• Empirical Formula (Hill Notation): C₁₂H₁₁N₇
• CAS Number: 396-01-0
• Molecular Weight: 253.26
• EC Number: 206-904-3
• MDL number: MFCD00006708
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277877
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥99%
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL; DMSO: soluble 5.4 mg/mL; H₂O: insoluble
• originator: Wellspring
• SMILES string: Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1
• InChI: 1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
• InChI key: FNYLWPVRPXGIIP-UHFFFAOYSA-N
• Gene Information: human ... SCNN1A(6337), SCNN1B(6338), SCNN1G(6340)

Description

Application

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions². Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay³.

Biochem/physiol Actions

Weak diuretic with potassium sparing properties; blocks Na⁺ reuptake in the kidneys.

Features and Benefits

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves