C0605

Z-Asp(O-Me)-Glu(O-Me)-Val-Asp(O-Me) fluoromethyl ketone

≥90% (HPLC)

• Synonym(s): Z-DEVD-FMK
• Empirical Formula (Hill Notation): C₃₀H₄₁N₄O₁₂F
• CAS Number: 210344-95-9
• Molecular Weight: 668.66
• MDL number: MFCD23380217
• UNSPSC Code: 12352200
• PubChem Substance ID: 329774802

Properties

• Assay: ≥90% (HPLC)
• form: powder
• color: off-white
• solubility: DMSO: ≥20 mg/mL, clear
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: COC(=O)CC[C@H](NC(=O)[C@H](CC(=O)OC)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF
• InChI: 1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1
• InChI key: GBJVAVGBSGRRKN-JYEBCORGSA-N

Description

Biochem/physiol Actions

A cell-permeable inhibitor of caspase 3, 6, 7, 8, 10, which exhibits competitive and irreversible inhibition.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves