ED4SS

Ethylenediaminetetraacetic acid tetrasodium salt dihydrate

Name: Ethylenediaminetetraacetic acid tetrasodium salt dihydrate
Brand: SIGMA

99.0-102.0% (titration)

Synonym(s):

EDTA tetrasodium salt, Edathamil, Tetrasodium ethylenediaminetetraacetate dihydrate

Sign Into View Organizational & Contract Pricing

About This Item

Linear Formula:

(NaOOCCH₂)₂NCH₂CH₂N(CH₂COONa)₂ · 2H₂O

CAS Number:

10378-23-1

Molecular Weight:

416.20

Beilstein:

3861753

EC Number:

200-573-9

MDL number:

MFCD00150026

UNSPSC Code:

12352202

PubChem Substance ID:

24894711

NACRES:

NA.77

Key Documents

View All Documentation

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Quality Level

300

Assay

99.0-102.0% (titration)

form

crystalline

reaction suitability

reagent type: chelator

solubility

H₂O: soluble, clear, colorless

SMILES string

O.O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.4Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;2*1H2/q;4*+1;;/p-4

InChI key

KSYNLCYTMRMCGG-UHFFFAOYSA-J

General description

Ethylenediaminetetraacetic acid (EDTA) is a polyprotic acid and a metal chelating agent. It comprises four carboxylic acid and two amine groups with lone-pair electrons that can chelate calcium and several other metal ions.

Application

Ethylenediaminetetraacetic acid tetrasodium salt dihydrate has been used:

in the decalcification of femurs for the histoprocessing and staining of osteochondral tissue
as a component of NH₄Cl lysis buffer for erythrocyte lysis and bulk characterization
for the isolation of crypts from the connective tissues of mice

Biochem/physiol Actions

Ethylenediaminetetraacetic acid (EDTA) is used to eliminate enzyme inhibition by traces of heavy metals, and to inhibit enzymes that require divalent cations as cofactors.

Ethylenediaminetetraacetic acid (EDTA) is used to treat patients poisoned with heavy metal ions. It functions as a chelator of the zinc ion in the active site of metalloproteases. EDTA inhibits other metal ion-dependent proteases such as calcium-dependent cysteine proteases. It might interfere with biological events which are metal ion-dependent. EDTA inhibits platelet aggregation and is the most preferred anticoagulant for platelet counts. It associates with other active agents to modulate microorganisms and biofilms, like citric acid, alcohol, antibiotics, polyhexamethylene biguanide (PHMB) quaternary ammonium compounds, and other antiseptics. EDTA is used as an anticoagulant for hematological testing, as it preserves the cellular components and morphology of blood cells.

Still not finding the right product?

Explore all of our products under Ethylenediaminetetraacetic acid tetrasodium salt dihydrate