M6690

MDL 28170

≥90% (TLC)

• Synonym(s): Calpain Inhibitor III
• Empirical Formula (Hill Notation): C₂₂H₂₆N₂O₄
• CAS Number: 88191-84-8
• Molecular Weight: 382.45
• MDL number: MFCD00798796
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278565
• NACRES: NA.77

Properties

• Quality Level: 200
• Assay: ≥90% (TLC)
• composition: Peptide Content, >90%
• solubility: DMSO: 26 mg/mL; H₂O: insoluble; methanol: soluble
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: [H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C
• InChI: 1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1
• InChI key: NGBKFLTYGSREKK-ANYOKISRSA-N
• Gene Information: human ... CAPN1(823), CAPN2(824)

Description

Amino Acid Sequence

Z-Val-Phe-al

Application

MDL 28170 has been used as a calpain inhibitor:

• to study its effects on neuroinflammation and necroptosis in rat model of cardiac arrest
• to analyze its effects on the degradation of neuronal nitric oxide synthase (nNOS) in beef semimembranosus muscle
• to study its protective effects against traumatic brain injury and survival of bone marrow-derived mesenchymal stem cells (BMSCs) in rat brain

Biochem/physiol Actions

MDL 28170 exhibits neuroprotective effects against spinal cord injury, focal cerebral ischemia, and neonatal hypoxia-ischemia in rats. It also shows anti-inflammatory and anti-neurodegenerative properties. MDL 28170 crosses the blood-brain barrier and penetrates readily through the cell membranes.

MDL 28170 is a potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Reduced occurrence of apoptosis in H₂O₂ and A23187 treated PC12 cells. γ-secretase-inhibitor.

Potent cell permeable calpain I and II inhibitor; reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves