DPP4-M

DPP IV Inhibitor

• Synonim(y): Inhibitor DPP IV, Inhibitor peptydazy dipeptydylowej 4
• Kod UNSPSC: 41116012
• eCl@ss: 32160405
• NACRES: NC.07

Właściwości

• Formularz: solution
• Poziom jakości: 100
• numer dostępu NCBI: NM_001935.3
• numer dostępu UniProt: P27487
• informacje o genach: human ... DPP4(1803)

Opis

Opis ogólny

Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.

Zastosowanie

Research Category
All

Działania biochem./fizjol.

Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). It′s a promising therapeutic target for type 2 diabetes (T2DM). In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors. DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.

Przechowywanie i stabilność

Upon arrival, store at 4°C. For long-term of more than 2 weeks, store at –20°C.

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