C1919

Chloramphenicol

Name: Chloramphenicol
Brand: SIGMA

BioReagent, suitable for plant cell culture

Synonim(y):

D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin

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About This Item

Wzór liniowy:

Cl₂CHCONHCH(CH₂OH)CH(OH)C₆H₄NO₂

CAS Number:

56-75-7

Masa cząsteczkowa:

323.13

Beilstein:

2225532

Numer WE:

200-287-4

Numer MDL:

MFCD00078159

Kod UNSPSC:

51102831

Identyfikator substancji w PubChem:

24892448

NACRES:

NA.76

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Pomoc techniczna

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Pomoc techniczna

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Pozwól nam pomóc

linia produktu

BioReagent

Poziom jakości

200

Formularz

powder

metody

cell culture | plant: suitable

zanieczyszczenia

Endotoxin, tested

mp

149-153 °C (lit.)

spektrum działania antybiotyku

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Zastosowanie

agriculture

Tryb działania

protein synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O

InChI

1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1

Klucz InChI

WIIZWVCIJKGZOK-RKDXNWHRSA-N

informacje o genach

human ... CYP1A2(1544)

Opis ogólny

Chemical structure: phenicole

Zastosowanie

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Działania biochem./fizjol.

Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.

Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.

Przestroga

Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.

Uwaga dotycząca przygotowania

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Inne uwagi

Keep container tightly closed in a dry and well-ventilated place, Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

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