H7772

Hygromycin B from Streptomyces hygroscopicus

Name: Hygromycin B from <I>Streptomyces hygroscopicus</I>
Brand: SIGMA

lyophilized powder

Synonim(y):

Hygrovetine

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About This Item

Wzór empiryczny (zapis Hilla):

C₂₀H₃₇N₃O₁₃

CAS Number:

31282-04-9

Masa cząsteczkowa:

527.52

Numer WE:

250-545-5

Numer MDL:

MFCD06795479

Kod UNSPSC:

51102829

Identyfikator substancji w PubChem:

24895807

NACRES:

NA.85

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Pomoc techniczna

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Pozwól nam pomóc

Pomoc techniczna

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Pozwól nam pomóc

pochodzenie biologiczne

Streptomyces hygroscopicus

Poziom jakości

200

Formularz

lyophilized powder

oczyszczone przez

ion-exchange chromatography

kolor

faintly brown to brown
white to beige

rozpuszczalność

H₂O: 50 mg/mL

spektrum działania antybiotyku

viruses

Tryb działania

protein synthesis | interferes

temp. przechowywania

2-8°C

ciąg SMILES

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@]4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

Klucz InChI

GRRNUXAQVGOGFE-XKIAHZFYSA-N

Opis ogólny

Chemical structure: aminoglycoside

Zastosowanie

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes..

Działania biochem./fizjol.

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Przestroga

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

Uwaga dotycząca przygotowania

This product is purified by ion exchange chromatography. Hygromycin B is soluble in water at concentrations >50 mg/mL, and also soluble in methanol or ethanol. Solutions should be sterilized by filtration, not by autoclaving. Additionally, Hygromycin B solutions have been reported to lose activity on freezing, and since they are stable refrigerated, freezing should be avoided.

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