100625

3-Amino-1,2,4-triazine

97%

• Synonym(s): 3-Amino-as-triazine, [1,2,4]Triazin-3-ylamine
• Empirical Formula (Hill Notation): C₃H₄N₄
• CAS Number: 1120-99-6
• Molecular Weight: 96.09
• EC Number: 214-324-7
• MDL number: MFCD00006459
• UNSPSC Code: 12352100
• PubChem Substance ID: 24846419
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• mp: 174-177 °C (lit.)
• SMILES string: Nc1nccnn1
• InChI: 1S/C3H4N4/c4-3-5-1-2-6-7-3/h1-2H,(H2,4,5,7)
• InChI key: MJIWQHRXSLOUJN-UHFFFAOYSA-N

Description

General description

3-amino-1,2,4-triazine (ATN) acts as a single molecular carbon nitride precursor during the preparation of mesoporous carbon nitride with high nitrogen content via polymerization. Additionally, it is also used in the synthesis of organometal complexes.

Application

• Antitumor activity in pharmaceutical applications: A study reported the development of a new library of 3-Amino-1,2,4-Triazine derivatives as PDK1 inhibitors, showing significant antitumor activity against pancreatic ductal adenocarcinoma, indicating its potential in cancer therapeutics (Carbone et al., 2023).
• Structural analysis in crystallography: The crystal structure and Hirshfeld surface analysis of a complex involving 3-Amino-1,2,4-triazine was detailed, providing insights into the molecular interactions and potential applications in materials science and coordination chemistry (Sangeetha et al., 2018).
• Catalytic applications in NMR technology: 3-Amino-1,2,4-triazine was used in a study to achieve significant NMR polarization in water using the SABRE technique, demonstrating its role as a catalyst in enhancing NMR sensitivity and its utility in magnetic resonance imaging (Zeng et al., 2014).

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves