125504

Cyclopropylamine

98%

• Synonym(s): Aminocyclopropane
• Linear Formula: C₃H₅NH₂
• CAS Number: 765-30-0
• Molecular Weight: 57.09
• Beilstein/REAXYS Number: 741858
• EC Number: 212-142-2
• MDL number: MFCD00001301
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847670
• NACRES: NA.22

Properties

• vapor pressure: 4.67 psi ( 20 °C)
• Quality Level: 200
• assay: 98%
• form: liquid
• autoignition temp.: 527 °F
• refractive index: n20/D 1.420 (lit.)
• bp: 49-50 °C (lit.)
• density: 0.824 g/mL at 25 °C (lit.)
• SMILES string: NC1CC1
• InChI: 1S/C3H7N/c4-3-1-2-3/h3H,1-2,4H2
• InChI key: HTJDQJBWANPRPF-UHFFFAOYSA-N

Description

Application

Cyclopropylamine(CPA) has been used in the synthesis of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It has been used in the synthesis of Pt(CPA)₂(bismethylthiomethylenepropanedioate) and Pt(CPA)₂(bisethylthiomethylenepropanedioate) complexes.

Biochem/physiol Actions

Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H302,H314
• pcodes: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 33.8 °F - closed cup
• flash_point_c: 1 °C - closed cup
• ppe: Faceshields, Gloves, Goggles