144185

2,4-Dichloro-6-methylpyrimidine

98%

• Empirical Formula (Hill Notation): C₅H₄Cl₂N₂
• CAS Number: 5424-21-5
• Molecular Weight: 163.00
• EC Number: 226-563-4
• MDL number: MFCD00006064
• UNSPSC Code: 12352100
• PubChem Substance ID: 24848638
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 98%
• form: solid
• bp: 219 °C (lit.)
• mp: 44-47 °C (lit.)
• functional group: chloro
• SMILES string: Cc1cc(Cl)nc(Cl)n1
• InChI: 1S/C5H4Cl2N2/c1-3-2-4(6)9-5(7)8-3/h2H,1H3
• InChI key: BTLKROSJMNFSQZ-UHFFFAOYSA-N

Description

General description

2,4-Dichloro-6-methylpyrimidine undergoes double cross-coupling reaction with 2-(tributylstannyl)pyridine, followed by aldol condensation to yield 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines. It reacts with 1H,1H,2H,2H-perfluorodecanethiol during fluorous synthesis of disubstituted pyrimidines.

Application

2,4-Dichloro-6-methylpyrimidine was used in the synthesis of (2-chloro-6-methyl-pyrimidin-4-yl)-(2,3-dihydro-benzothiazol-6-yl)-amine.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 235.4 °F - closed cup
• flash_point_c: 113 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges