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144436

Sigma-Aldrich

Isobutyramide

99%

Synonym(s):

2-Methylpropionamide

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About This Item

Linear Formula:
(CH3)2CHCONH2
CAS Number:
563-83-7
Molecular Weight:
87.12
EC Number:
209-265-9
MDL number:
MFCD00008019
UNSPSC Code:
12352100
PubChem Substance ID:
24848653
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

100

assay

99%

form

solid

bp

216-220 °C (lit.)

mp

127-131 °C (lit.)

density

1.013 g/mL at 25 °C (lit.)

functional group

amide

SMILES string

CC(C)C(N)=O

InChI

1S/C4H9NO/c1-3(2)4(5)6/h3H,1-2H3,(H2,5,6)

InChI key

WFKAJVHLWXSISD-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
398128204846205559
Ammonium metavanadate puriss. p.a., ACS reagent, ≥99.0% (RT)

10028

Ammonium metavanadate

Ammonium metavanadate ACS reagent, ≥99.0%

398128

Ammonium metavanadate

Ammonium metavanadate 99.95% trace metals basis

204846

Ammonium metavanadate

Ammonium metavanadate 99%

205559

Ammonium metavanadate

form

powder or crystals

form

powder

form

crystalline

form

powder, crystals or granules

assay

≥99.0% (RT)

assay

≥99.0%

assay

99.95% trace metals basis

assay

99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

grade

ACS reagent, puriss. p.a.

grade

ACS reagent

grade

-

grade

-

pH

7 (20 °C, 5.1 g/L)

pH

7 (20 °C, 5.1 g/L)

pH

-

pH

7 (20 °C, 5.1 g/L)

anion traces

chloride (Cl-): ≤2000 mg/kg, sulfate (SO42-): ≤100 mg/kg, phosphate (PO43-): ≤50 mg/kg

anion traces

carbonate (CO32-): passes test, chloride (Cl-): ≤0.2%, sulfate (SO42-): ≤0.05%

anion traces

-

anion traces

-

Application

Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules[1].

Biochem/physiol Actions

Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene[2]. It is useful in the treatment of β-thalassemia and sickle cell disease[2].

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    WXBD4954V
    WXBD2847V
    MKCM6379
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    MKCK4648

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    J Zhang et al.
    Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 16(4), 187-193 (2003-08-09)
    To examine the effect of isobutyramide synthesized in our laboratory on human and murine globin gene expression and to test cell toxicity of the drug. MEL cells were transfected with the recombinant construct muLCRAgammapsibetadeltabeta and the stable transformants were cultured
    S P Perrine et al.
    The American journal of pediatric hematology/oncology, 16(1), 67-71 (1994-02-01)
    Stimulating expression of the normal fetal globin genes is a preferred method of ameliorating sickle cell disease and beta-thalassemia for the majority of patients in North America who do not have appropriate bone marrow donors. Due to increased survival of
    G B Strambini et al.
    Biochemistry, 29(1), 203-208 (1990-01-09)
    The phosphorescence properties of liver alcohol dehydrogenase from horse were characterized at limiting concentrations of coenzyme and coenzyme analogues. The emission decay kinetics of Trp-314 in strong, slowly exchanging, ternary complexes with NADH/isobutyramide, NAD/pyrazole, and NADH/dimethyl sulfoxide displays a markedly
    M D Cappellini et al.
    Annals of the New York Academy of Sciences, 850, 110-119 (1998-07-21)
    The aims of this study were to ascertain tolerability, safety and efficacy of oral isobutyramide (150 mg/kg bw/day) in stimulating fetal hemoglobin production in twelve thalassemia intermedia patients. Patients were treated for 28 days and followed for a further 28
    Thermosensitive molecular assemblies from poly(amidoamine) dendron-based lipids.
    Kenji Kono et al.
    Angewandte Chemie (International ed. in English), 50(28), 6332-6336 (2011-05-21)
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