15149

N,N-Bis(phosphonomethyl)glycine

≥98.0% (T)

• Synonym(s): N-(Carboxymethyl)iminodi(methylphosphinic acid), Glyphosine
• Empirical Formula (Hill Notation): C₄H₁₁NO₈P₂
• CAS Number: 2439-99-8
• Molecular Weight: 263.08
• Beilstein/REAXYS Number: 1884944
• EC Number: 219-468-4
• MDL number: MFCD00056670
• UNSPSC Code: 12352100
• PubChem Substance ID: 329750747
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥98.0% (T)
• functional group: amine; carboxylic acid
• SMILES string: O=P(CN(CP(O)(O)=O)CC(O)=O)(O)O
• InChI: 1S/C4H11NO8P2/c6-4(7)1-5(2-14(8,9)10)3-15(11,12)13/h1-3H2,(H,6,7)(H2,8,9,10)(H2,11,12,13)
• InChI key: OXHDYFKENBXUEM-UHFFFAOYSA-N

Description

General description

N,N-Bis(phosphonomethyl)glycine was present in the ligand bound to human apotransferrin.

Application

Application: Complexing agent; pK-values: pK1: ·2, pK2: 2.0, pK3: 5.20, pK4: 6.77, pK5: 10.89

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Glyphosine binds to a pocket of MHC class II molecules I-Ag7 and DQ8, and modify T cell responses to the autoantigenic insulin B chain fragment 9–23 (B:9–23) peptide. Glyphosine stimulate IL-10 production and delay onset of diabetes in non-obese NOD mice.†

Biochem/physiol Actions

Anti-diabetic; delay onset of diabetes in non-obese NOD mice

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves