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191140

Sigma-Aldrich

7-Aminocephalosporanic acid

98%

Synonym(s):

7-ACA

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About This Item

Empirical Formula (Hill Notation):
C10H12N2O5S
CAS Number:
957-68-6
Molecular Weight:
272.28
Beilstein/REAXYS Number:
622637
EC Number:
213-485-0
MDL number:
MFCD00005177
UNSPSC Code:
12352106
PubChem Substance ID:
24851470
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

200

assay

98%

form

powder

optical activity

[α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH

reaction suitability

reaction type: solution phase peptide synthesis

mp

>300 °C (lit.)

antibiotic activity spectrum

Gram-positive bacteria

application(s)

peptide synthesis

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

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HPA035821AMAB91163HPA028911
Anti-CDK5RAP2 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

HPA046529

Anti-CDK5RAP2 antibody produced in rabbit

Anti-CDK5RAP2 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

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Anti-CDK5RAP2 antibody produced in rabbit

Monoclonal Anti-CDK5RAP2 antibody produced in mouse Prestige Antibodies® Powered by Atlas Antibodies, clone CL3392, purified immunoglobulin

AMAB91163

Monoclonal Anti-CDK5RAP2 antibody produced in mouse

Anti-HOXC8 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

HPA028911

Anti-HOXC8 antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

product line

Prestige Antibodies® Powered by Atlas Antibodies

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

General description

Chemical structure: ß-lactam

Application

7-Aminocephalosporanic acid (7-ACA) can be used as a starting material to synthesize:
  • Cefotaxime by acylation reaction with S-benzothiazol-2-yl(2-amino-4-thiazolyl)(methoxyimino)thioacetate (MAEM) in the presence of triethylamine.[1]
  • Cefpodoxime proxetil, a third-generation antibiotic via cefotaxime intermediate.[1]
  • Sodium 3′-substituted cephalosporanate sulfone derivatives as potential inhibitors of β-lactamase.[2]

Potent inhibitor of bacterial (S. aureus) β-lactamase.[3]

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKBZ8828V
    MKBR1128V
    MKBL2298V
    MKBK3641V
    MKBG4776V

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    Denis L Atroshenko et al.
    International journal of molecular sciences, 20(18) (2019-09-11)
    d-amino acid oxidase (DAAO, EC 1.4.3.3) is used in many biotechnological processes. The main industrial application of DAAO is biocatalytic production of 7-aminocephalosporanic acid from cephalosporin C with a two enzymes system. DAAO from the yeast Trigonopsis variabilis (TvDAAO) shows
    Cosmin Butnarasu et al.
    International journal of pharmaceutics, 564, 136-144 (2019-04-17)
    Mucin is a complex glycoprotein consisting of a wide variety of functional groups that can interact with exogenous agents. The binding to mucin plays a crucial role in drug pharmacokinetics especially in diseases, such as cystic fibrosis (CF), where mucin
    Synthesis and Preliminary Biological Evaluation of 3?-Substituted Cephem Sulfones as Potential β-Lactamase Inhibitors
    De Angelis F, et al.
    European Journal of Organic Chemistry, 2001(16), 3075-3081 (2001)
    Zhanglin Lin et al.
    Biotechnology and bioengineering, 117(10), 2923-2932 (2020-06-17)
    Site-directed protein immobilization allows the homogeneous orientation of proteins with high retention of activity, which is advantageous for many applications. Here, we report a facile, specific, and efficient strategy based on the SpyTag-SpyCatcher chemistry. Two SpyTag-fused model proteins, that is
    Irene Martínez-Martínez et al.
    Analytical biochemistry, 369(2), 210-217 (2007-07-27)
    A bromothymol blue-based colorimetric assay has been devised to screen for acetyl xylan esterase or cephalosporin C (CPC) deacetylase activities using 7-amino cephalosporanic acid (7-ACA), CPC, or acetylated xylan as substrate. These enzymes are not screened with their natural substrates
    View All Related Papers

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