232270

3-Amino-5-methylisoxazole

≥97%

• Synonym(s): 5-Methyl-3-isoxazolamine, NSC 159134
• Empirical Formula (Hill Notation): C₄H₆N₂O
• CAS Number: 1072-67-9
• Molecular Weight: 98.10
• Beilstein/REAXYS Number: 108110
• EC Number: 214-013-6
• MDL number: MFCD00003155
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853889
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: ≥97%
• form: solid
• mp: 59-61 °C (lit.)
• SMILES string: Cc1cc(N)no1
• InChI: 1S/C4H6N2O/c1-3-2-4(5)6-7-3/h2H,1H3,(H2,5,6)
• InChI key: FKPXGNGUVSHWQQ-UHFFFAOYSA-N

Description

General description

3-Amino-5-methylisoxazole is the major intermediate formed during sulfamethoxazole biodegradation by Pseudomonas psychrophila strain HA-4. It is the intermediate formed during the photocatalytic degradation of sulfamethoxazole (SMX).

Application

3-Amino-5-methylisoxazole was used in synthesis of:

• naphtho[1,2-e][1,3]oxazines
• series of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones, having potential mosquito larvicidal activity
• hydroxylamines of sulfadiazine and sulfamethoxazole

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)