253340

3-Quinuclidinol

99%

• Synonym(s): 1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine
• Empirical Formula (Hill Notation): C₇H₁₃NO
• CAS Number: 1619-34-7
• Molecular Weight: 127.18
• Beilstein/REAXYS Number: 80122
• EC Number: 216-578-4
• MDL number: MFCD00151326
• UNSPSC Code: 12352100
• PubChem Substance ID: 24855306
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 99%
• mp: 220-223 °C (lit.)
• functional group: hydroxyl
• SMILES string: OC1CN2CC[C@H]1CC2
• InChI: 1S/C7H13NO/c9-7-5-8-3-1-6(7)2-4-8/h6-7,9H,1-5H2
• InChI key: IVLICPVPXWEGCA-UHFFFAOYSA-N

Description

General description

(R)-3-Quinuclidinol is a valuable compound for the production of various pharmaceuticals.

Application

3-Quinuclidinol has been used:

• as chiral building block for many antimuscarinic agents
• in chemoselective α−iodination of various simple and multi-functionalised acrylic esters via Morita-Baylis-Hillman protocol
• as reagent for cleavage of β-keto and vinylogous β-keto esters
• as synthon for the preparation of cholinergic receptor ligands and anesthetics
• as catalyst for condensation of methyl vinyl ketone with aldehydes

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges