270121
Methyl (S)-(+)-3-hydroxy-2-methylpropionate
97%
Synonym(s):
(+)-Methyl L-β-hydroxyisobutyrate, (S)-(+)-3-Hydroxy-2-methylpropionic acid methyl ester
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About This Item
Linear Formula:
HOCH2CH(CH3)CO2CH3
CAS Number:
Molecular Weight:
118.13
Beilstein/REAXYS Number:
1720830
MDL number:
UNSPSC Code:
12352108
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
assay
97%
form
liquid
optical activity
[α]19/D +26°, c = 4 in methanol
optical purity
ee: 99% (GLC)
refractive index
n20/D 1.425 (lit.)
bp
74 °C/10 mmHg (lit.)
density
1.071 g/mL at 25 °C (lit.)
functional group
ester
hydroxyl
SMILES string
COC(=O)[C@@H](C)CO
Related Categories
Application
Methyl (S)-(+)-3-hydroxy-2-methylpropionate may be used as a starting material in the total synthesis of (+)-discodermolide, a potent antimitotic agent.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
176.0 °F - closed cup
flash_point_c
80 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Total synthesis of the antimicrotubule agent (+)-discodermolide using boron-mediated aldol reactions of chiral ketones.
Paterson I, et al.
Angewandte Chemie (International Edition in English), 39(2), 377-380 (2000)
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