336106

2,6-Lutidine

• Synonym(s): 2,6-Dimethylpyridine
• Empirical Formula (Hill Notation): C₇H₉N
• CAS Number: 108-48-5
• Molecular Weight: 107.15
• Beilstein/REAXYS Number: 105690
• EC Number: 203-587-3
• MDL number: MFCD00006345
• UNSPSC Code: 12352005
• PubChem Substance ID: 24860356
• NACRES: NA.22

Properties

• assay: ≥99.0 %
• Quality Level: 300
• form: liquid
• refractive index: n20/D 1.497 (lit.)
• bp: 143-145 °C (lit.)
• mp: −6 °C (lit.)
• solubility: water: 163.130 g/L at 25 °C
• density: 0.92 g/mL at 25 °C (lit.)
• SMILES string: Cc1cccc(C)n1
• InChI: 1S/C7H9N/c1-6-4-3-5-7(2)8-6/h3-5H,1-2H3
• InChI key: OISVCGZHLKNMSJ-UHFFFAOYSA-N

Description

General description

2,6-Lutidine, also known as 2,6-dimethylpyridine, is an organic compound that is commonly used as a reagent in various organic reactions, such as the synthesis of heterocycles, nitroalkenes, and alkyl halides. It can also be used as a catalyst in organic synthesis.

Application

2,6-Lutidine can be used as:

• A base in the synthesis of an aldol adduct from malonic acid hemithioesters and aldehydes catalyzed by Cu(II) salt.
• An additive in reductive cyclization of epoxygeranyl acetate.
• A catalyst in combination with CuI for selective synthesis of N-sulfonyl-1,2,3-triazoles.

Safety Information

• pictograms: GHS02,GHS07
• signalword: Warning
• hcodes: H226,H302,H315,H319
• pcodes: P210 - P233 - P240 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 89.6 °F
• flash_point_c: 32 °C
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter