362425

2-Chloro-N-methoxy-N-methylacetamide

98%

• Linear Formula: ClCH₂CON(OCH₃)CH₃
• CAS Number: 67442-07-3
• Molecular Weight: 137.56
• MDL number: MFCD00134232
• UNSPSC Code: 12352100
• PubChem Substance ID: 24862311
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 98%
• form: solid
• mp: 39-41 °C (lit.)
• functional group: amine; chloro
• storage temp.: 2-8°C
• SMILES string: CON(C)C(=O)CCl
• InChI: 1S/C4H8ClNO2/c1-6(8-2)4(7)3-5/h3H2,1-2H3
• InChI key: SCOJKGRNQDKFRP-UHFFFAOYSA-N

Description

General description

2-Chloro-N-methoxy-N-methylacetamide is a Weinreb amide.[1]

Application

2-Chloro-N-methoxy-N-methylacetamide may be used in the preparation of:

• 2-heptyl-3-hydroxy-4(1H)-quinolone (Pseudomonas quinolone signal or PQS) and structurally related 2-alkyl-4-quinolones having biological activity[1]
• 2-(benzo[d]thiazol-2-ylsulfonyl)-N-methoxy-N-methylacetamide[2]
• α-chloro-ketone, starting reagent for the one-pot synthesis of 2-heptyl-3-hydroxyl-4(1H)-quinolone (PQS), signalling molecule in the quorum sensing of Pseudomonas aeruginosa[3]

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 219.2 °F - closed cup
• flash_point_c: 104 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves