370622

4-(Trifluoromethoxy)benzyl bromide

97%

• Linear Formula: CF₃OC₆H₄CH₂Br
• CAS Number: 50824-05-0
• Molecular Weight: 255.03
• MDL number: MFCD00061238
• UNSPSC Code: 12352100
• PubChem Substance ID: 24863081
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• form: liquid
• refractive index: n20/D 1.48 (lit.)
• bp: 82-84 °C/10 mmHg (lit.)
• density: 1.594 g/mL at 25 °C (lit.)
• functional group: bromo; fluoro
• SMILES string: FC(F)(F)Oc1ccc(CBr)cc1
• InChI: 1S/C8H6BrF3O/c9-5-6-1-3-7(4-2-6)13-8(10,11)12/h1-4H,5H2
• InChI key: JDNPUJCKXLOHOW-UHFFFAOYSA-N

Description

General description

Polymerizations of 4-(trifluoromethoxy)benzyl bromide, via Friedel-Crafts polymerization using aluminum chloride as a catalyst has been reported.

Application

4-(Trifluoromethoxy)benzyl bromide may be used in the synthesis of bioreductive drug, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314
• pcodes: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 201.2 °F - closed cup
• flash_point_c: 94 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter