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40407

Sigma-Aldrich

1,7-Dimethyluric acid

≥97.0% (HPLC)

Synonym(s):

1,7-Dimethyl-2,6,8-trihydroxypurine

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About This Item

Empirical Formula (Hill Notation):
C7H8N4O3
CAS Number:
33868-03-0
Molecular Weight:
196.16
Beilstein/REAXYS Number:
219682
EC Number:
251-706-2
MDL number:
MFCD00005713
UNSPSC Code:
12352100
PubChem Substance ID:
57649989
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

100

assay

≥97.0% (HPLC)

SMILES string

CN1C(=O)NC2=C(N(C)C(=O)N2)C1=O

InChI

1S/C7H8N4O3/c1-10-3-4(8-6(10)13)9-7(14)11(2)5(3)12/h1-2H3,(H,8,13)(H,9,14)

InChI key

NOFNCLGCUJJPKU-UHFFFAOYSA-N

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species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

Gene Information

human ... TIMP1(7076)

Gene Information

human ... TIMP2(7077)

Gene Information

human ... VCAM1(7412)

Gene Information

human ... VEGFA(7422)

input

sample type tissue lysate
sample type cell lysate

input

sample type urine
sample type cell culture supernatant(s)
sample type serum
sample type plasma

input

sample type serum
sample type plasma
sample type cell culture supernatant(s)
sample type urine

input

sample type cell lysate
sample type tissue lysate

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 30 pg/mL
standard curve range: 24.69-18000 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 pg/mL
standard curve range: 1.6-1200 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 300 pg/mL
standard curve range: 0.247-60 ng/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/mL
standard curve range: 8.23-6000 pg/mL

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

technique(s)

ELISA: suitable, capture ELISA: suitable

General description

1,7-Dimethyluric acid is an important metabolite of caffeine.[1] Electrochemical oxidation of 1,7-dimethyluric acid was studied over a wide pH range of 2.2-10.3 at solid electrodes.[2]

Application

1,7-Dimethyluric acid is the suitable reagent used for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine or caffeine metabolites by HPLC.[1]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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    BCCF3606
    BCBW5333
    BCBQ3254V
    BCBL4683V
    BCBD2600V

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    Electrochemical and peroxidase catalysed oxidation of 1, 7-dimethyluric acid and effect of methyl groups on the oxidation mechanism.
    Goyal RN, et al.
    J. Chem. Soc. Perkin Trans. II, 6, 1153-1159 (1996)
    Emma Gracia-Lor et al.
    The Science of the total environment, 747, 141331-141331 (2020-08-18)
    Smoking cigarettes and drinking coffee are common habits in today's society. However, it is not easy to get up-to-date information on smoking prevalence and caffeine consumption as it is usually obtained from population surveys. To overcome this limitation and complement
    J Kizu et al.
    Biomedical chromatography : BMC, 13(1), 15-23 (1999-04-07)
    A high performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of plasma levels of theophylline and its metabolites without interference from caffeine or caffeine metabolites. The method is simple and of practical use because it is
    M T Landi et al.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 5(9), 693-698 (1996-09-01)
    Cytochrome P4501A2 (CYP1A2) activity may be related to bladder cancer risk through metabolic activation of aromatic amines, such as 4-aminobiphenyl (ABP), to reactive intermediates that can form DNA and hemoglobin (Hb) adducts. In the context of a study on smoking
    M E Campbell et al.
    Clinical pharmacology and therapeutics, 42(2), 157-165 (1987-08-01)
    Systemic caffeine clearance and urinary metabolite profiles were determined in 15 subjects with diverse exposure histories to cytochrome P-450 inducers (cigarette smoke) and inhibitors (oral contraceptive steroids). A correlation was observed between caffeine clearance and a urinary ratio based on
    View All Related Papers

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