469599

Ethyl chlorodifluoroacetate

98%

• Linear Formula: ClCF₂CO₂C₂H₅
• CAS Number: 383-62-0
• Molecular Weight: 158.53
• EC Number: 206-850-0
• MDL number: MFCD00013662
• UNSPSC Code: 12352100
• PubChem Substance ID: 24870471
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 98%
• refractive index: n20/D 1.358 (lit.)
• bp: 96-97.5 °C (lit.)
• density: 1.252 g/mL at 25 °C (lit.)
• functional group: chloro; ester; fluoro
• SMILES string: CCOC(=O)C(F)(F)Cl
• InChI: 1S/C4H5ClF2O2/c1-2-9-3(8)4(5,6)7/h2H2,1H3
• InChI key: GVCAWQUJCHZRCB-UHFFFAOYSA-N

Description

General description

Ethyl chlorodifluoroacetate (ECDFA) undergoes Reformatskii reaction with various aldehydes in DMF. It reacts with phenylacetylene to afford ethyl α,α−difluoro-4-phenyl-3-butenoates.

Application

Ethyl chlorodifluoroacetate (ECDFA) may be used as a starting reagent in the synthesis of 3-gem-difluoro-2-ethoxy allylic alcohols.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H225,H314
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 64.4 °F - closed cup
• flash_point_c: 18 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter