498270

1-Chloro-N,N,2-trimethyl-1-propenylamine

96%

• Synonym(s): Ghosez′s reagent
• Linear Formula: (CH₃)₂C=C(Cl)N(CH₃)₂
• CAS Number: 26189-59-3
• Molecular Weight: 133.62
• MDL number: MFCD00800562
• UNSPSC Code: 12352302
• PubChem Substance ID: 24873186
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 96%
• refractive index: n20/D 1.453 (lit.)
• bp: 129-130 °C (lit.)
• density: 1.01 g/mL at 25 °C (lit.)
• functional group: amine; chloro
• storage temp.: 2-8°C
• SMILES string: CN(C)\C(Cl)=C(\C)C
• InChI: 1S/C6H12ClN/c1-5(2)6(7)8(3)4/h1-4H3
• InChI key: GQIRIWDEZSKOCN-UHFFFAOYSA-N

Description

Application

1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.

Safety Information

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H226,H314
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Flam. Liq. 3 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 80.0 °F - closed cup
• flash_point_c: 26.67 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter