56413

2-Pyridinol 1-oxide

≥98.0% (N)

• Synonym(s): 1-Hydroxy-2-pyridone, 2-Hydroxypyridine 1-oxide, HOPO
• Empirical Formula (Hill Notation): C₅H₅NO₂
• CAS Number: 13161-30-3
• Molecular Weight: 111.10
• Beilstein/REAXYS Number: 1422545
• EC Number: 236-100-8
• MDL number: MFCD00006195
• UNSPSC Code: 12352005
• PubChem Substance ID: 57651579
• NACRES: NA.22

Properties

• Quality Level: 300
• assay: ≥98.0% (N)
• form: solid
• mp: 147-152 °C
• SMILES string: Oc1cccc[n+]1[O-]
• InChI: 1S/C5H5NO2/c7-5-3-1-2-4-6(5)8/h1-4,7H
• InChI key: JVHZMYAXZUIZKS-UHFFFAOYSA-N

Description

General description

2-Pyridinol 1-oxide (HOPO) is a peptide coupling agent used as a subsititue for HOBt. It can form stable chelate complexes with transition metal ions.

Application

2-Pyridinol 1-oxide can be used:    

• To fabricate gold electrodes for the electrochemical determination of europium using cyclic voltammetry.        
• To prepare polymeric nickel (II) complex of 2-hydroxypyridine-N-oxide.
• In the synthesis of 1-methoxypyrid-4-one in the presence of sodium methoxide and methyl toluene-9-sulphonate.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315 - H319 - H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: 212.0 °F - closed cup
• flash_point_c: 100 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Gloves