Skip to Content
MilliporeSigma
All Photos(2)

Key Documents

View All Documentation

804088

Sigma-Aldrich

SnAP 2-Spiro-(4-Pip) M Reagent

Synonym(s):

tert-butyl 4-(aminomethyl)-4-((tributylstannyl)methoxy)piperidine-1-carboxylate

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

Empirical Formula (Hill Notation):
C24H50N2O3Sn
Molecular Weight:
533.38
UNSPSC Code:
12352103
PubChem Substance ID:
329768843
NACRES:
NA.22
Pricing and availability is not currently available.

form

liquid

refractive index

n/D 1.492

density

1.146

functional group

amine
ether

storage temp.

−20°C

SMILES string

CCCC[Sn](CCCC)(COC1(CCN(C(OC(C)(C)C)=O)CC1)CN)CCCC

InChI

1S/C12H23N2O3.3C4H9.Sn/c1-11(2,3)17-10(15)14-7-5-12(9-13,16-4)6-8-14;3*1-3-4-2;/h4-9,13H2,1-3H3;3*1,3-4H2,2H3;

InChI key

LEBKPKYDLQUOJO-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
EHU152321EHU158371EHU121211
MISSION® esiRNA targeting human BORCS8-MEF2B

EHU147601

MISSION® esiRNA

MISSION® esiRNA targeting human NANOGNB

EHU152321

MISSION® esiRNA

MISSION® esiRNA targeting human TREH, PHLDB1

EHU158371

MISSION® esiRNA

MISSION® esiRNA targeting human BANF1

EHU121211

MISSION® esiRNA

esiRNA cDNA target sequence

CCAGGGAGCCATCTACACTGTGGAGTACGCCTGCAGCGCCGTGAAGAACCTGGTGGACAGCAGCGTCTACTTCCGCAGCGTGGAGGGTCTGCTCAAACAGGCCATCAGCATCCGGGACCATATGAATGCCAGTGCCCAGGGCCACAGCCCGGAGGAACCACCCCCGCCCTCCTCAGCCTGATCCTGGAAGAGACTCGGGGCCCCCCAGCCTCCGCCAACCCAGACAAAGATCATTCCACTCAGCCTGGGACGATGGGGAGGAAAAAAATCCAGATCTCCCGCATCCTGGACCAAAGGAATCGGCAGGTGACGTTCACCAAGCGGAAGTTCGGGCTGATGAAGAA

esiRNA cDNA target sequence

GCTATGCCTTGGGATCAAGATCCAGAACAATCAACTGGAAATTACAGTGAAGATGAACAAAATGGAAAGCAGAAATGGAGAGAAGAAGGAGAAGCAGGCAGAAAGAGAGAACGAGAAAAAGAAGAAAAAAACGAAAAGGAGCTGCAAGATGAACAGGAAAACAAAAGGAAAAGGGAAAATGAGAAACAGAAACAGTATCCCGAGAAAAGATTAGTCAGCAAATCCCTCATGCATACTCTCTGGGCAAAGTTTAAGTTAAACAGGTGCCCCACTATACAAGAGAGTCTATCACTGTCATTTGAATTTGACATGACACATAAACAGATAAGTCAATGGTTTTGTAAAACGAGGAAGAAATATAATAAAGAAATGTCCAAGAGAAAGCATAAGAAAAAACATATGAGATGGAGATCTCTGTGTTGCCAAGGCT

esiRNA cDNA target sequence

CTCCATCCCCTAGTTGCAGACTCATCACCATGGTTACCATAGTGACTGCTTCATTGCCATGGTTACATACTAATTGCTGCAGCTCTGTGGCCCAGCCCACTGCTTCAGCTGTGGGCCATCTGAGGGTACGTGCCATCATCTCTCCAGCCCAGGCCCCTGGGCATCTCATGCTGGGGGGAAGGGACTGAATACCTTTTTCCTTCCCCCTGCCTGTGTCTTCAGCCCTGATGCACAGGCTGCCAGCCCCCCAGTCCAGCCCTCTCCCTTCCACTGGTGCCTTGCTTAGAGCCAGAAGGGATGAAGCCGGGGGATCTATGGAACAGAGGAGGAGCGATGCAGTTGGGAGAGGAAGCTAGAAGGGTTATGGTTGGAGTTCTGTACAGTGTTGAGTTTCCGACAGGGAA

esiRNA cDNA target sequence

CTCTCCCTGGAGGCCTATCTCCCTCAGAACTGCGCGAGAAGCGAGACCTTAGAAGGCAGGGCTTCCCGCGAAGGACCGGAAAGGAGCGCCTACTAAGGACGCCGTCGAGGTCCGGGGCGCCTCAACTCTATAGCTCTAACTGGCTAGAAGTGCCCAACGTGGAATGTTTCTTTTTTAAAGGCGGCTCTTGAAGCGACCCGGAAGCGGAAGTGGAAGAAAGTTCTAGTGGCTTGAGGTATCCGCAGGAGCGGCCGGGTGGCGGGAGGAACCGTTACGGGAACTGAAGTTGCGGATTAAGCCTGATCAAGATGACAACCTCCCAAAAGCACCGAGACTTCGTGGCAGAGCCCATGGGGGAGAAGCCAGTGGGGAGCCTGGCTGGGATTGGTGAAGTCCTGGGCAAGAAG

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Gene Information

human ... MEF2B(4207)

Gene Information

human ... NANOGNB(360030)

Gene Information

human ... TREH(11181), PHLDB1(23187)

Gene Information

human ... BANF1(8815)

Ensembl | human accession no.

ENSG00000064489

Ensembl | human accession no.

ENSG00000205857

Ensembl | human accession no.

ENSG00000019144

Ensembl | human accession no.

ENSG00000175334

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

NCBI accession no.

NM_001145785

NCBI accession no.

NM_001145465

NCBI accession no.

NM_001144758

NCBI accession no.

NM_001143985

General description

SnAP (Sn amino protocol)[1] reagents have been developed by the Bode group SnAP reagents are air and moisture stable. They can be prepared by simple reactions with cheap raw materials.[1] SnAP 2-Spiro-(4-Pip) M, also referred to as SnAP 2-spiro-(4-piperdine) morpholine, is a regioisomeric SnAP reagent. This reagent can be prepared from N-Boc piperidone.[2]

Application

SnAP Reagents provide a one-step route, in tandem with various aldehyde substrates, to saturated N-heterocycles. The synthesis of N-heterocycles through SnAP Reagents requires mild reaction conditions, and aldehydes bearing aryl, heteroaryl, glyoxyl, aliphatic, and halogenated groups are well tolerated. This product was introduced in collaboration with the Bode Research Group
SnAP 2-Spiro-(4-Pip) M Reagent may be used for the preparation of unprotected, saturated N-heterocyclic compounds, C-substituted bicyclic and spirocyclic morpholines.[3]

Automate your N-heterocycle formation with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Technology spotlight: SnAP Reagents
Professor product portal: Jeffrey Bode Research Group
SnAP Reagents for the Synthesis of Piperazines and Morpholines
SnAP reagents for the one-step synthesis of medium-ring saturated N-heterocycles from aldehydes
SnAP Reagents for a Cross-Coupling Approach to the One-Step Synthesis of Saturated N-Heterocycles
Bespoke SnAP Reagents for the Synthesis of C-Substituted Spirocyclic and Bicyclic Saturated N-Heterocycles

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT RE 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

>230.0 °F

flash_point_c

> 110 °C

  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

    It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

    If you need assistance, please contact Customer Support

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Simona Pavan et al.
    Oncogene, 37(31), 4197-4213 (2018-05-02)
    An epithelial to mesenchymal transition (EMT) has been correlated to malignant tumor progression and metastasis by promoting cancer cell migration and invasion and chemoresistance. Hence, finding druggable EMT effectors is critical to efficiently interfere with metastasis formation and to overcome

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service