86734

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid

≥97.0% (CHN)

• Synonym(s): DOTA
• Empirical Formula (Hill Notation): C₁₆H₂₈N₄O₈ · xH₂O
• CAS Number: 60239-18-1
• Molecular Weight: 404.42 (anhydrous basis)
• Beilstein/REAXYS Number: 1186987
• MDL number: MFCD00068657
• UNSPSC Code: 12352005
• PubChem Substance ID: 57653192
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥97.0% (CHN)
• form: powder
• functional group: carboxylic acid
• SMILES string: OC(=O)CN1CCN(CCN(CCN(CC1)CC(O)=O)CC(O)=O)CC(O)=O
• InChI: 1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)
• InChI key: WDLRUFUQRNWCPK-UHFFFAOYSA-N

Description

Application

1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.

• It has been used for radiolabeling of carbon nanotube bioconjugates by chelating ⁶⁴Cu radioisotope.
• DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
• It can form complexes with gadolinium for application as MRI contrast agents.
• Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves