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Key Documents

923273

2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid

Name: 2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid
Brand: ALDRICH

Synonym(s):

Rigid linker for PROTAC^® development

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₃N₃O₄S

Molecular Weight:

353.44

UNSPSC Code:

12352106

NACRES:

NA.22

Pricing and availability is not currently available.

form

powder

Quality Level

100

reaction suitability

reagent type: linker

functional group

Boc
carboxylic acid

storage temp.

2-8°C

SMILES string

[H][C@]12[C@](N(C(OC(C)(C)C)=O)CC2)([H])CN(C3=NC(C(O)=O)=CS3)CC1

InChI

1S/C16H23N3O4S/c1-16(2,3)23-15(22)19-7-5-10-4-6-18(8-12(10)19)14-17-11(9-24-14)13(20)21/h9-10,12H,4-8H2,1-3H3,(H,20,21)/t10-,12-/m0/s1

InChI key

JQJPLRYBMMRMOU-JQWIXIFHSA-N

Related Categories

Chemical Biology

Protein Degrader Building Blocks

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This Item	RAB1786	RAB1806	RAB1807
RAB1787 Rhesus Macaque Angiopoietin-1 ELISA	RAB1786 Rhesus Macaque Angiostatin ELISA	RAB1806 Rhesus Macaque IGFBP-1 ELISA	RAB1807 Rhesus Macaque IGFBP-2 ELISA
species reactivity rhesus macaque	species reactivity rhesus macaque	species reactivity rhesus macaque	species reactivity rhesus macaque
Gene Information rhesus macaque ... ANGPT1(697017)	Gene Information rhesus macaque ... PLG(703891)	Gene Information rhesus macaque ... IGFBP1(696994)	Gene Information rhesus macaque ... IGFBP2(696214)
assay range inter-assay cv: <12% intra-assay cv: <10%	assay range inter-assay cv: <12% intra-assay cv: <10%	assay range inter-assay cv: <12% intra-assay cv: <10%	assay range inter-assay cv: <12% intra-assay cv: <10%
input sample type serum sample type plasma sample type cell culture supernatant(s)	input sample type plasma sample type serum sample type cell culture supernatant(s)	input sample type cell culture supernatant(s) sample type plasma sample type serum	input sample type cell culture supernatant(s) sample type plasma sample type serum
technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) ELISA: suitable	technique(s) ELISA: suitable
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Application

2-((3aR,7aR)-1-(tert-Butoxycarbonyl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)thiazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:

923281

923303

Other Notes

Protein Degrader Building Blocks

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

related product

Product No.

Description

Pricing

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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