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923931

Sigma-Aldrich

Pomalidomide-4-piperidine-C1-piperazine hydrochloride

Synonym(s):

2-(2,6-Dioxopiperidin-3-yl)-4-(4-(piperazin-1-ylmethyl)piperidin-1-yl)isoindoline-1,3-dione hydrochloride, Crosslinker−E3 ligase ligand conjugate, Protein degrader building block

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About This Item

Empirical Formula (Hill Notation):
C23H29N5O4 · xHCl
Molecular Weight:
439.51 (free base basis)
MDL number:
UNSPSC Code:
41116105
NACRES:
NA.21

Pricing and availability is not currently available.

ligand

pomalidomide

Quality Level

reaction suitability

reactivity: carboxyl reactive
reagent type: ligand-linker conjugate

functional group

amine

storage temp.

2-8°C

SMILES string

O=C1C(N2C(C(C=CC=C3N(CC4)CCC4CN5CCNCC5)=C3C2=O)=O)CCC(N1)=O.Cl

InChI

1S/C23H29N5O4.ClH/c29-19-5-4-18(21(30)25-19)28-22(31)16-2-1-3-17(20(16)23(28)32)27-10-6-15(7-11-27)14-26-12-8-24-9-13-26;/h1-3,15,18,24H,4-14H2,(H,25,29,30);1H

InChI key

HICUONDYEDHQSV-UHFFFAOYSA-N

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This Item
923877923885923958
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

reaction suitability

reactivity: carboxyl reactive, reagent type: ligand-linker conjugate

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

ligand

pomalidomide

ligand

pomalidomide

ligand

pomalidomide

ligand

6F,C5-Pomalidomide

functional group

amine

functional group

amine

functional group

amine

functional group

amine

Application

Protein degrader building block Pomalidomide-4-piperidine-C1-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. This conjugate contains a Cereblon (CRBN) recruiting ligand, a rigid linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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