D95654

Diethyl fumarate

98%

• Synonym(s): (2E)-2-Butenedioic acid diethyl ester, (E)-But-2-enedioic acid diethyl ester, Diethyl (E)-but-2-enedioate, Diethyl fumaric acid ester, Ethyl fumarate
• Linear Formula: C₂H₅OCOCH=CHCOOC₂H₅
• CAS Number: 623-91-6
• Molecular Weight: 172.18
• Beilstein/REAXYS Number: 775347
• EC Number: 210-819-7
• MDL number: MFCD00064455
• UNSPSC Code: 12352100
• PubChem Substance ID: 24894309
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 98%
• form: liquid
• refractive index: n20/D 1.44 (lit.)
• bp: 218-219 °C (lit.)
• mp: 1-2 °C (lit.)
• density: 1.052 g/mL at 25 °C (lit.)
• SMILES string: [H]\C(=C(\[H])C(=O)OCC)C(=O)OCC
• InChI: 1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5+
• InChI key: IEPRKVQEAMIZSS-AATRIKPKSA-N

Description

General description

Diethyl fumarate is an electrophilic compound, commonly used in the Diels-Alder reaction.

Application

• Relaxation and Amorphous Structure of Polymers: This study examines the behavior of polymers with rigid fumarate segments, including diethyl fumarate, and their impact on the relaxation and amorphous structures, enhancing polymer design and processing (Suzuki et al., 2022).


• Gradient versus End-Capped Degradable Polymer Sequence Variations: The research explores the mechanical properties of photochemically 3D-printed substrates using diethyl fumarate-based polymers, presenting new possibilities in creating tailored biomaterials for medical applications (Shin and Becker, 2022).


• Novel Curcumin-Diethyl Fumarate Hybrid for Parkinson′s Disease: This study investigates a hybrid molecule combining curcumin and diethyl fumarate, highlighting its dual function as a GSK-3β inhibitor and Nrf2 inducer, which could be significant for Parkinson′s disease treatment strategies (Di Martino et al., 2020).


• Synthesis and 3D Printing of PEG-Poly(propylene fumarate) Copolymers: This article describes the synthesis and application of diethyl fumarate in the creation of novel diblock and triblock copolymer hydrogels for 3D printing, expanding the utility in biomedicine and tissue engineering (Dilla et al., 2018).

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 197.6 °F - closed cup
• flash_point_c: 92 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter