QBD10314

MAL-dPEG^®₂₄-NHS ester

• Synonym(s): Polyethylene glycol
• Empirical Formula (Hill Notation): C₆₂H₁₁₁N₃O₃₁
• Molecular Weight: 1394.55
• MDL number: MFCD11041160
• UNSPSC Code: 12352108
• PubChem Substance ID: 329823914
• NACRES: NA.22

Properties

• assay: >90%
• form: solid or viscous liquid
• reaction suitability: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• polymer architecture: shape: linear; functionality: heterobifunctional
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCN2C(C=CC2=O)=O
• InChI: 1S/C62H111N3O31/c66-57(5-8-64-58(67)1-2-59(64)68)63-7-10-73-12-14-75-16-18-77-20-22-79-24-26-81-28-30-83-32-34-85-36-38-87-40-42-89-44-46-91-48-50-93-52-54-95-56-55-94-53-51-92-49-47-90-45-43-88-41-39-86-37-35-84-33-31-82-29-27-80-25-23-78-21-19-76-17-15-
• InChI key: GRDUWUCYIIEBIS-UHFFFAOYSA-N

Description

Features and Benefits

MAL-dPEG^® ₂₄-NHS ester is a heterobifunctional, linear crosslinking reagents containing a maleimide group on one end of the single molecular weight dPEG^® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG^® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. N-hydroxysuccinimide (NHS) ester are used widely in reactions with primary amines. The NHS-amine reactions can be carried out in aqueous or organic solvent. The dPEG^® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

Legal Information

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Safety Information

• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable