W222208

Isobutyric acid

≥99%, FCC, FG

• Synonym(s): Isobutanoic acid, 2-Methylpropionic acid
• Linear Formula: (CH₃)₂CHCO₂H
• CAS Number: 79-31-2
• Molecular Weight: 88.11
• FEMA Number: 2222
• Beilstein/REAXYS Number: 635770
• EC Number: 201-195-7
• Council of Europe no.: 6
• MDL number: MFCD00002658
• UNSPSC Code: 12164502
• PubChem Substance ID: 24900936
• Flavis number: 8.006
• NACRES: NA.21
• Organoleptic: butter; acidic; rancid
• Grade: FG; Kosher
• Biological source: synthetic
• Agency: meets purity specifications of JECFA
• Food allergen: no known allergens

Properties

• biological source: synthetic
• Quality Level: 300; 400
• grade: FG; Kosher
• agency: meets purity specifications of JECFA
• reg. compliance: EU Regulation 1334/2008 & 872/2012; FCC; FDA 21 CFR 172.515
• vapor density: 3.04 (vs air)
• vapor pressure: 1.5 mmHg ( 20 °C)
• assay: ≥99%
• autoignition temp.: 824 °F
• expl. lim.: 10 %

Description

General description

Isobutyric acid is a volatile fatty acid that can be used as a flavoring agent. It occurs naturally in Ceratonia siliqua L. The gum obtained from the kernels of this species is used as a thickener in the food industry.

Application

• Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody.: This study presents groundbreaking research on how isobutyric acid can enhance the efficacy of anti-PD-1 antibodies, offering significant implications for improving cancer immunotherapy treatments (Murayama et al., 2024).

Biochem/physiol Actions

Odor at 10 ppm

Taste at 15 ppm

Other Notes

Natural occurrence: Roman chamomile, strawberry, dairy products.

Safety Information

• pictograms: GHS02,GHS06,GHS05
• signalword: Danger
• hcodes: H226,H302,H311,H314
• pcodes: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 131.0 °F - closed cup
• flash_point_c: 55 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter