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16-319

Sigma-Aldrich

Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate

purified antibody, clone 23A8, from mouse

Synonym(s):

Cell migration-inducing gene 5 protein, Ras-like protein TC25, migration-inducing gene 5, migration-inducing protein 5, ras-related C3 botulinum toxin substrate 1, ras-related C3 botulinum toxin substrate 1 (rho family,small GTP binding protein Rac1), ra

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

23A8, monoclonal

species reactivity

human, rat, mouse

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

NP_008839

UniProt accession no.

P63000

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... RAC1(5879)

General description

Rac1 is a member of a RhoGTPase subfamily (Rac1-Rac4) that transduces extracellular signals from G-coupled protein receptors (GPCR), integrins and growth factor receptors to effector molecules that modulate multiple signaling pathways. While Rac1 supports the activation of MAPkinase pathways and gene activation, it’s most important functions include the regulation of cytoskeletal structures. Together with Rho (regulator of stress fibers) and Cdc42 (regulator of filopodia), Rac modulates the formation of focal adhesion (FA) complexes; membrane ruffles and lamellipodia that contribute to important cell functions related to cell attachment and movement.

Specificity

Other species have not been tested.
Recognizes human Rac1.

Application

Anti-Rac1 Antibody, clone 23A8, Magnetic bead Conjugate detects level of Rac1 & has been published & validated for use in WB & IP.

Target description

21 kDa

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt. DO NOT FREEZE! Wash the magnetic beads with an appropriate buffer prior to use to remove sodium azide.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

Certificates of Analysis (COA)

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Mian Zhou et al.
Cellular & molecular immunology, 20(1), 80-93 (2022-12-06)
In sepsis, macrophage bacterial phagocytosis is impaired, but the mechanism is not well elucidated. Extracellular cold-inducible RNA-binding protein (eCIRP) is a damage-associated molecular pattern that causes inflammation. However, whether eCIRP regulates macrophage bacterial phagocytosis is unknown. Here, we reported that
Zihang Chen et al.
The Journal of physiology, 598(12), 2415-2430 (2020-04-03)
Spinal cord dorsal horn srGAP3 (slit-robo GTPase activating protein 3) increases in the initiation phase of neuropathic pain and decreases in the maintenance phase. However, Rac1 activity, which can be reduced by srGAP3, decreases in the initiation phase and increases

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