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204878

Sigma-Aldrich

Complement C1r, Human, Activated, Two-Chain Form

Complement C1r, Human, Activated, Two-Chain Form, CAS 80295-34-7, is a native, activated, C1r complement component.

Synonym(s):

Complement C1r, Human, Activated, Two-Chain Form

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About This Item

CAS Number:
80295-34-7
MDL number:
MFCD00270206
UNSPSC Code:
12352202
NACRES:
NA.25
Pricing and availability is not currently available.

Quality Level

100

assay

≥90% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

impurities

IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH, trace

shipped in

wet ice

storage temp.

−70°C

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204873C1740204885
Complement C1r, Human, Activated, Two-Chain Form Complement C1r, Human, Activated, Two-Chain Form, CAS 80295-34-7, is a native, activated, C1r complement component.

204878

Complement C1r, Human, Activated, Two-Chain Form

Complement C1, Human Complement C1, Human Native, is the first component of the classical complement pathway. It is a calcium-dependent complex of C1q, C1r, and C1s subcomponents.

204873

Complement C1, Human

Complement component C1q from human serum ≥95% (SDS-PAGE)

C1740

Complement component C1q from human serum

Complement C3, Human Complement C3, Human, CAS 80295-41-6, is a native C3 component. Glycoprotein composed of two non-identical disulfide-bonded subunits of 115 kDa (α) and 75 kDa (β).

204885

Complement C3, Human

assay

≥90% (SDS-PAGE)

assay

-

assay

≥95% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

form

liquid

form

liquid

form

liquid

form

liquid

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage condition

-

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

impurities

IgG, IgA, IgM, albumin, C1s, C4BP, C1-INH, trace

impurities

-

impurities

-

impurities

IgG, IgA, IgM, C4, functionally active C5, albumin or ceruloplasmin, trace

General description

Native, human, activated, C1r complement component. Generally, non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to the classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35,000 peptide contains C1r enzymatic active site. Activated C1r continues activation via the classical pathway by cleaving, and thus activating C1s.

Biochem/physiol Actions

≥80% of C1r will bind with excess C1-INH

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Villiers, C.L., et al. 1983. Biochem. J. 215, 369.
Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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