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Key Documents

205530

Sigma-Aldrich

CA-074

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

CA-074, Cathepsin B Inhibitor III, [L-3- trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline

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About This Item

Empirical Formula (Hill Notation):
C18H29N3O6
Molecular Weight:
383.44
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

colorless to white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

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1316040283424122
Benzyl alcohol ReagentPlus®, ≥99%

108006

Benzyl alcohol

Benzyl alcohol puriss. p.a., ACS reagent, ≥99.0% (GC)

13160

Benzyl alcohol

Benzyl alcohol ACS reagent, ≥99.0%

402834

Benzyl alcohol

Benzyl alcohol puriss., meets analytical specification of Ph. Eur., BP, NF, 99-100.5% (GC)

24122

Benzyl alcohol

assay

≥99%

assay

≥99.0% (GC)

assay

≥99.0%

assay

99-100.5% (GC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: soluble 33 g/L at 20 °C

solubility

H2O: 33 mg/mL at 20 °C, clear, colorless

solubility

-

solubility

-

form

liquid

form

liquid

form

liquid

form

liquid

refractive index

n20/D 1.539 (lit.)

refractive index

n20/D 1.539 (lit.), n20/D 1.541

refractive index

n20/D 1.539 (lit.)

refractive index

n20/D 1.539 (lit.), n20/D 1.539-1.541

autoignition temp.

817 °F

autoignition temp.

817 °F

autoignition temp.

817 °F

autoignition temp.

817 °F

General description

A potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B).
An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).

Biochem/physiol Actions

Cell permeable: no
Primary Target
cathepsin B
Product does not compete with ATP.
Reversible: no
Target IC50: 2.24 nM for rat liver cathepsin B

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, V.J., et al. 1999. Biochem. J. 340, 113.
Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
Yamamoto, A., et al. 1997. J. Biochem.121, 974.
Inubushi, T., et al. 1994. J. Biochem. 116, 282.
Murata, M., et al. 1991. FEBS Lett. 280, 307.
Towatari, T., et al. 1991. FEBS Lett. 280, 311.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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    Anneliese S Ashhurst et al.
    bioRxiv : the preprint server for biology (2021-01-06)
    The emergence of SARS-CoV-2 in late 2019, and the subsequent COVID-19 pandemic, has led to substantial mortality, together with mass global disruption. There is an urgent need for novel antiviral drugs for therapeutic or prophylactic application. Cathepsin L is a

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