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211280

Sigma-Aldrich

Capsazepine

A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

Synonym(s):

Capsazepine, N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

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About This Item

Empirical Formula (Hill Notation):
C19H21ClN2O2S
CAS Number:
Molecular Weight:
376.90
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: soluble
methanol: soluble

shipped in

ambient

storage temp.

10-30°C

SMILES string

S=C(N2CCCc3c(cc(c(c3)O)O)C2)NCCc1ccc(cc1)Cl

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1 of 4

This Item
WH0000197M1SAB4200746SAB4200760
Gene Information

human ... AHSG(197)

Gene Information

human ... AHSG(197)

Gene Information

human ... AFP(174)

Gene Information

human ... FN1(2335)

clone

FetA-M, monoclonal

clone

5D8, monoclonal

clone

C3, monoclonal

clone

FN-15, monoclonal

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

species reactivity

human

species reactivity

human

species reactivity

human, canine, porcine

species reactivity

human, mouse

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

A competitive antagonist of Capsaicin (Cat. No. 211274) and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.
A competitive antagonist of the sensory neuron excitants capsaicin (Cat. No. 211274) and resiniferatoxin (Cat. No. 553975). Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

Biochem/physiol Actions

Cell permeable: no
Primary Target
A competitive antagonist of Capsaicin and resiniferatoxin
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Fox, A.J., et al. 1995. Neuroscience 67, 741.
Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
Walpole, C.S.J., et al. 1994. J. Med. Chem.37, 1942.
Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap.267, 728.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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