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238900

Sigma-Aldrich

4-Cyano-3-methylisoquinoline

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM).

Synonym(s):

4-Cyano-3-methylisoquinoline, PKA Inhibitor XI

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About This Item

Empirical Formula (Hill Notation):
C11H8N2
CAS Number:
161468-32-2
Molecular Weight:
168.19
MDL number:
MFCD02179199
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

n1cc2c(c(c1C)C#N)cccc2

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conjugate

fluorescein conjugate

conjugate

fluorescein conjugate

conjugate

fluorescein conjugate

conjugate

fluorescein conjugate

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

goat

biological source

goat

biological source

goat

biological source

goat

technique(s)

direct immunofluorescence: suitable, indirect immunofluorescence: suitable, indirect ELISA: suitable

technique(s)

direct immunofluorescence: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

technique(s)

direct immunofluorescence: suitable, flow cytometry: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

technique(s)

direct immunofluorescence: suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable

species reactivity

mouse

species reactivity

mouse

species reactivity

human

species reactivity

rabbit

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKA
Product competes with ATP.
Reversible: yes
Target IC50: 30 nM against protein kinase A

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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