356310
Glyburide
A sulfonylurea that selectively blocks ATP-sensitive K+ channels.
Synonym(s):
Glyburide, Glybenclamide
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About This Item
Empirical Formula (Hill Notation):
C23H28ClN3O5S
CAS Number:
Molecular Weight:
494.00
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
description
Merck USA index - 14, 4478
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 25 mg/mL
ethanol: 5 mg/mL
shipped in
ambient
storage temp.
10-30°C
General description
A sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. Inhibits the vasorelaxing effects of nitric oxide.
Antidiabetic sulfonylurea that selectively blocks ATP-sensitive K+ channels. Reduced K+ conductance causes membrane depolarization and influx of Ca2+ through voltage sensitive Ca2+ channels. Blocks vascular smooth muscle relaxation produced by KATP channel openers. High-affinity binding sites are widely distributed and have been identified in the cardiovascular system, the central nervous system, and pancreatic β-cells. In cultured cells, glyburide enhances insulin action and stimulates the synthesis of glucose transporters. Displays large potency difference in action on pancreatic tissue (IC50 in nM range) and vascular tissue (IC50 in µM range).
Biochem/physiol Actions
Cell permeable: no
Primary Target
ATP-sensitive K+ channels
ATP-sensitive K+ channels
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Holzmann, S., et al. 1992. Eur. J. Pharmacol.215, 1.
Rabuazzo, A.M., et al. 1992. Endocrinology131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther.256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.
Rabuazzo, A.M., et al. 1992. Endocrinology131, 1815.
Miller, J.A., et al. 1991. J. Pharmacol. Exp. Ther.256, 358.
Jacobs, D.R., et al. 1989. Diabetes 38, 205.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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