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516485

Pepstatin A Methyl Ester

Name: Pepstatin A Methyl Ester
Brand: MM

A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase.

Synonym(s):

Pepstatin A Methyl Ester, Isovaleryl-V V-Sta-A-Sta-OCH₃, PME

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About This Item

Empirical Formula (Hill Notation):

C₃₅H₆₅N₅O₉

Molecular Weight:

699.92

UNSPSC Code:

12352108

NACRES:

NA.77

Pricing and availability is not currently available.

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

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This Item	1.07667	1.07237	1.07232
1.01342 LEVINE-EMB-agar	1.07667 SS agar	1.07237 BPLS agar	1.07232 BPLS agar
form powder (dehydrated (DCM))	form medium granules (dehydrated (DCM))	form medium granules (dehydrated (DCM))	form medium granules (dehydrated (DCM))
technique(s) microbiological culture: suitable	technique(s) microbiological culture: suitable	technique(s) microbiological culture: suitable	technique(s) microbiological culture: suitable
suitability Enterobacter spp., Escherichia coli	suitability Salmonella spp., Shigella spp.	suitability Salmonella spp.	suitability Salmonella spp.
application(s) clinical microbiology	application(s) food and beverages microbiology	application(s) clinical microbiology	application(s) clinical microbiology
solubility 36 g/L	solubility 60 g/L	solubility 52 g/L	solubility 52 g/L
pH 7.1 (37 °C, 36 g/L in H₂O, after autoclaving)	pH 7.0-7.2 (37 °C, 60 g/L in H₂O, after autoclaving)	pH 6.7-7.1 (25 °C in H₂O)	pH 6.8-7.0 (37 °C, 52 g/L in H₂O, after autoclaving)

General description

A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (K_is = 150 nM, K_ii = 320 nM in solubilized human γ-secretase at 20°C; K_is is the inhibition constant for inhibitor binding to the free enzyme and K_ii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Other Notes

Tian, G., et al. 2002. J. Biol. Chem.277, 31499.
Zhang, L., et al. 2001. Biochemistry40, 5049.
Murphy, M.P., et al. 1999. J. Biol. Chem.274, 11914.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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