565850
Shikonin
≥98% (HPLC), solid, Pyruvate kinase inhibitor, Calbiochem®
Synonym(s):
Shikonin, Pyruvate Kinase Inhibitor II
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About This Item
Empirical Formula (Hill Notation):
C16H16O5
CAS Number:
Molecular Weight:
288.30
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Product Name
Shikonin, A naphthoquinone found in the Chinese herb Shiunko.
Quality Level
description
RTECS - QL8000200
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
red
solubility
DMSO: 10 mg/mL
shipped in
ambient
General description
A naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC50<1 µM) over PKM1 and PKL activities (IC50 in the range of 10-20 µM), and inhibits cancer cell glycolysis.
Biochem/physiol Actions
Cell permeable: no
Primary Target
TNF-α-induced and B-16 melanoma-induced angiogenesis
TNF-α-induced and B-16 melanoma-induced angiogenesis
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chen, J., et al. 2011. Oncogene30, 4297.
Li, H., et al. 1999. Phytother. Res.13, 236.
Yoon, Y., et al. 1999. Planta Med.65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.
Li, H., et al. 1999. Phytother. Res.13, 236.
Yoon, Y., et al. 1999. Planta Med.65, 532.
Hisa, T., et al. 1998. Anticancer Res. 18, 783.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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