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568500

Sigma-Aldrich

SQ 22536

Cell-permeable adenylate cyclase inhibitor.

Synonym(s):

SQ 22536, 9-(Tetrahydro-2ʹ-furyl)adenine

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25 μG
221,00 $
100 μG
564,00 $

221,00 $


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25 μG
221,00 $
100 μG
564,00 $

About This Item

Empirical Formula (Hill Notation):
C9H11N5O
CAS Number:
Molecular Weight:
205.22
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

221,00 $


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Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 25 mg/mL
water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]2(c3ncnc(c3nc2)N)C1OCCC1

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This Item
574102288104S153
SQ 22536 Cell-permeable adenylate cyclase inhibitor.

568500

SQ 22536

SQ 22,536 ≥97% (HPLC), powder

S153

SQ 22,536

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

form

solid

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

storage temp.

2-8°C

storage temp.

10-30°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: 25 mg/mL, water: 5 mg/mL

solubility

DMSO: 25 mg/mL, ethanol: 5 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

General description

Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC50 = 200 µM). Reduces PGE2-induced inhibition of O2· production.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
adenylate cyclase
Product does not compete with ATP.
Reversible: no
Target IC50: 200 µM against adenylate cyclase

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Other Notes

Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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