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Key Documents

575001

Sigma-Aldrich

α-Synuclein, Human, Recombinant, E. coli

Synonym(s):

NACP

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
Pricing and availability is not currently available.

biological source

human

Quality Level

100

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

suitability

suitable for molecular biology

shipped in

wet ice

storage temp.

−20°C

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Quality Level

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Quality Level

100

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction, reaction type: Heck Reaction, reaction type: Negishi Coupling, reaction type: Stille Coupling, reagent type: catalyst, reaction type: Cross Couplings, reaction type: Sonogashira Coupling, reaction type: Hiyama Coupling, reaction type: Suzuki-Miyaura Coupling

reaction suitability

-

form

solid

form

powder

composition

, ~5 wt. % (loading of catalyst)

composition

-

General description

Research area: Neuroscience

Recombinant, human α-synuclein expressed in E. coli. α-Synuclein is an acidic neuronal protein of 140 amino acids (amino acid residues 1 -140).

Application

α-Synuclein, Human, Recombinant, E. coli has been used to enhance the filter trap assay for identification of aggregated alpha-synuclein in brain samples.[1]

Biochem/physiol Actions

α-Synuclein been implicated in the pathogenesis of Parkinson’s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 20 mM Tris-HCl, 1 mM MgCl₂, pH 7.5.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Kahle, P.J, et al. 2001. Am. J. Pathol.159, 2215.
Kim, J. 1997. Mol. Cells7, 78.
Paik, S.R. 1997. Arch. Biochem. Biophys.344, 325.
Jakes, R., et al. 1994. FEBS Lett.345, 27.
Ueda, K., et al. 1993. Proc. Natl. Acad. Sci. USA90, 11282.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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